What are 3-part and 5-part Hematology Controls

3-part and 5-part Hematology Controls

What is 3-part and 5-part Hematology Controls? Hematology controls play a crucial role in ensuring the accuracy and precision of blood cell counting instruments. The terms “3-part” and “5-part” refer to the number of white blood cell differentials that are monitored by these controls. Let’s delve into each:

3-Part Hematology Controls


  • Differentials Monitored: 3-part controls are designed for hematology analyzers that provide a three-part differential count of white blood cells (WBCs).
  • Three Parts: The three parts typically include lymphocytes, monocytes, and granulocytes. Granulocytes further break down into subtypes: neutrophils, eosinophils, and basophils.


  • Accuracy Check: The primary purpose of 3-part controls is to monitor and verify the accuracy of the hematology analyzer in identifying and counting the three main types of white blood cells.
  • Routine Use: These controls are commonly used in routine hematology testing to ensure that the instrument is providing reliable results for the major components of the white blood cell population.


  • General Hematology Testing: 3-part controls are suitable for general hematology testing where a more detailed breakdown of white blood cell subtypes may not be required.

5-Part Hematology Controls


  • Differentials Monitored: 5-part controls are designed for hematology analyzers that provide a five-part differential count of white blood cells.
  • Five Parts: In addition to lymphocytes, monocytes, and three types of granulocytes, 5-part controls also monitor immature granulocytes, which include bands and metamyelocytes.


  • Extended Differential Count: The main purpose of 5-part controls is to monitor a more extended differential count, providing a detailed breakdown of various white blood cell types.
  • Specialized Testing: These controls are particularly valuable in scenarios where a more detailed analysis is required, such as in the diagnosis and monitoring of specific diseases, infections, or hematological disorders.


  • Specialized Hematology Testing: 5-part controls are commonly used in specialized hematology testing where a comprehensive understanding of the white blood cell population is necessary

Key Points

  • Accuracy Assurance: Both 3-part and 5-part controls are critical for ensuring the accuracy of hematology analyzers in identifying and counting white blood cells.
  • Clinical Relevance: The choice between 3-part and 5-part controls depends on the clinical requirements of the testing. Routine testing may benefit from 3-part controls,while more specialized or detailed testing may require the use of 5-part controls.


3-part and 5-part Hematology Controls with Vanguard Diagnostics

Ensuring precise and dependable blood counts and tests in clinical laboratories is contingent on the use of high-quality hematology controls. Vanguard Diagnostics, in collaboration with Diagon of Hungary, stands at the forefront of quality control leadership by providing exceptional 3-part and 5-part Hematology Controls. Notably, Diagon is among the exclusive two manufacturers of Hematology Controls globally. Through our collaborative efforts, we have introduced groundbreaking controls characterized by unparalleled shelf lives and open vial stabilities. This innovative stride empowers laboratories of all sizes in India to achieve results of the utmost reliability, aligning with international standards.

Vanguard Diagnostics’ commitment to elevating quality control in hematology is evident in our 3-part controls, boasting an extended shelf life of six months, a notable advancement surpassing competitors offering a mere three months. Similarly, our 5-part controls present a significant advantage with an extended four-month shelf life compared to competitor’s two months. These accomplishments solidify Vanguard Diagnostics’ position as a distinguished leader, delivering premium Hematology Controls to clinical laboratories globally