Typhoid RT PCR Test

It is a nucleic acid-based diagnostic assay for the detection of Typhoid using a Patented Technology (Patent No. 355208). It uses DNA isolated from the whole blood of infected humans and has been found to be highly sensitive and specific.

VANSCAN Typhoid RT PCR Test will ensure the definitive and early detection of Typhoid fever thus facilitating the administration of the right antibiotics for treatment. This will contribute significantly towards slowing down the threat from Antimicrobial Resistance (AMR) in India.

VANSCAN Typhoid RT PCR Test is an Industry-Academia Collaboration between Vanguard Diagnostics and Graphic Era University, Dehradun.

The Unmet Need

There has been an unmet need in the diagnostics space for the reliable and fast detection of Salmonella typhi and paratyphi – the causative organisms of Typhoid fever since long.

Early and accurate diagnosis of typhoid fever is imperative to initiate treatment by administering the right antibiotics and reducing the risk of Antimicrobial Resistance (AMR). Current methods of diagnosis include serology-based tests like the conventional WIDAL test and Rapid Card Tests and the blood culture test. The WIDAL test is more than 100 years old and the results obtained with it are largely unstandardized and inconclusive. Rapid Card Tests detect the presence of IgM and /or IgG antibodies to S.typhi.

Both these tests have been widely reported to suffer from the limitations of poor sensitivity, specificity, and reliability. The current gold standard is the blood culture test, however, it is cumbersome and time- consuming. The results of a blood culture test can be affected by intake of antibiotics.